Mus musculus Protein: Ywhag
Summary
InnateDB Protein IDBP-204181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ywhag
Protein Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Synonyms 14-3-3gamma; D7Bwg1348e;
Species Mus musculus
Ensembl Protein ENSMUSP00000051223
InnateDB Gene IDBG-204179 (Ywhag)
Protein Structure
UniProt Annotation
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 279 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 279 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030971 receptor tyrosine kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006605 protein targeting
GO:0032869 cellular response to insulin stimulus
GO:0045664 regulation of neuron differentiation
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031988 membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:108109
InterPro IPR000308 14-3-3 protein
IPR023410 14-3-3 domain
PFAM PF00244
PRINTS PR00305
PIRSF PIRSF000868
SMART SM00101
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61982
PhosphoSite PhosphoSite-P61982
TrEMBL A8IP69
UniProt Splice Variant
Entrez Gene 22628
UniGene Mm.490555
RefSeq NP_061359
MGI ID
MGI Symbol Ywhag
OMIM
CCDS CCDS19748
HPRD
IMGT
EMBL AB073970 AF058799 AK088847 AK148618 AK153307 AK164356 BC008129 CH466529 CT010208
GenPept AAC14345 AAH08129 BAC40609 BAE28625 BAE31888 BAE37756 BAF82002 CAJ18416 EDL19343