InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasa4

Summary

InnateDB Protein

IDBP-204287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasa4

Protein Name

RAS p21 protein activator 4

Synonyms

AA793972; AW112107; BB079060; CAPRI; GAPL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098136

InnateDB Gene

IDBG-204283 (Rasa4)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14. {ECO:0000269PubMed:16041389, ECO:0000269PubMed:16234249}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in osteoblasts. {ECO:0000269PubMed:16234249}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Protein Structure and Domains

PDB ID

MGI:1858600

InterPro

IPR000008 C2 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00779
PF00169
PF00616

PRINTS

PR00360
PR00402

PIRSF

SMART

SM00239
SM00107
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt