InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasa4

Summary

InnateDB Gene

IDBG-204283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasa4

Gene Name

RAS p21 protein activator 4

Synonyms

AA793972; AW112107; BB079060; CAPRI; GAPL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004952

Encoded Proteins

IDBP-204285

RAS p21 protein activator 4

IDBP-204287

RAS p21 protein activator 4

IDBP-536884

RAS p21 protein activator 4

IDBP-541247

RAS p21 protein activator 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105808:
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:136083916-136111860

Strand

Forward strand

Band

Transcripts

ENSMUST00000042135	ENSMUSP00000037869
ENSMUST00000100570	ENSMUSP00000098136
ENSMUST00000134509
ENSMUST00000125048
ENSMUST00000135344
ENSMUST00000131353
ENSMUST00000152723
ENSMUST00000140972
ENSMUST00000125247
ENSMUST00000145294	ENSMUSP00000120203
ENSMUST00000122887	ENSMUSP00000118929
ENSMUST00000130598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105808

View Gene Order

ENSBTAG00000005448

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.290655 Mm.487622 Mm.488795

RefSeq

NM_001039103 NM_133914 XM_006504443

OMIM

CCDS

CCDS39324 CCDS39325

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas