InnateDB Protein
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IDBP-204313.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdk5r1
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Protein Name
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cyclin-dependent kinase 5, regulatory subunit 1 (p35)
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Synonyms
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Cdk5r; D11Bwg0379e; p25; p35;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099514
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InnateDB Gene
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IDBG-204311 (Cdk5r1)
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Protein Structure
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Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269PubMed:17143272, ECO:0000269PubMed:24235147}.
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Subcellular Localization |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.Cyclin-dependent kinase 5 activator 1, p25: Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Brain and neuron specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:101764
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InterPro |
IPR004944
Cyclin-dependent kinase 5 activator
IPR013763
Cyclin-like
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PFAM |
PF03261
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PRINTS |
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PIRSF |
PIRSF009324
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
P61809
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PhosphoSite |
PhosphoSite-P61809
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TrEMBL |
Q542T9
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UniProt Splice Variant |
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Entrez Gene |
12569
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UniGene |
Mm.474282
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RefSeq |
NP_034001
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MGI ID |
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MGI Symbol |
Cdk5r1
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OMIM |
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CCDS |
CCDS25134
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HPRD |
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IMGT |
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EMBL |
AF121847
AK079557
AK141549
AK169667
AL591146
BC046823
BC050768
BC058697
CH466556
S82819
U89527
Y11335
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GenPept |
AAB46777
AAB49474
AAD21195
AAH46823
AAH50768
AAH58697
BAC37683
BAE24731
BAE41289
CAA72176
EDL15645
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