InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppox

Summary

InnateDB Protein

IDBP-204330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppox

Protein Name

protoporphyrinogen oxidase

Synonyms

Ppo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072863

InnateDB Gene

IDBG-204328 (Ppox)

Protein Structure

UniProt Annotation

Function

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. {ECO:0000269PubMed:8554330}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:3346226}; Peripheral membrane protein {ECO:0000269PubMed:3346226}; Intermembrane side {ECO:0000269PubMed:3346226}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0042493	response to drug
GO:0046501	protoporphyrinogen IX metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0031304	intrinsic to mitochondrial inner membrane
GO:0031305	integral component of mitochondrial inner membrane
GO:0031966	mitochondrial membrane