Version 5.4
Mus musculus Gene: Ppox
Summary
InnateDB Gene IDBG-204328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppox
Gene Name protoporphyrinogen oxidase
Synonyms Ppo
Species Mus musculus
Ensembl Gene ENSMUSG00000062729
Encoded Proteins
IDBP-204330
protoporphyrinogen oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143224:
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:171275990-171281186
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000073120 ENSMUSP00000072863
ENSMUST00000155083
ENSMUST00000152689
ENSMUST00000126765
ENSMUST00000145019
ENSMUST00000151442
ENSMUST00000133050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0042493 response to drug
GO:0046501 protoporphyrinogen IX metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0031304 intrinsic to mitochondrial inner membrane
GO:0031305 integral component of mitochondrial inner membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143224
View Gene Order
ENSBTAG00000021894
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_203298
Heme biosynthesis pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
INOH website
Porphyrin metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.266888 Mm.391664 Mm.404005 Mm.478548
RefSeq NM_008911 XM_006496707 XM_006496708
OMIM
CCDS CCDS15487
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca