Mus musculus Gene: Ppox | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Gene | IDBG-204328.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Ppox | ||||||||||||||
Gene Name | protoporphyrinogen oxidase | ||||||||||||||
Synonyms | Ppo | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Gene | ENSMUSG00000062729 | ||||||||||||||
Encoded Proteins |
protoporphyrinogen oxidase
|
||||||||||||||
Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143224:
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
||||||||||||||
Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 1:171275990-171281186 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | H3 | ||||||||||||||
Transcripts |
|
||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Orthologs | |||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||
Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Metabolism pathway
Heme biosynthesis pathway
Metabolism of porphyrins pathway
|
||||||||||||||
KEGG |
Porphyrin and chlorophyll metabolism pathway
|
||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Heme biosynthesis pathway
Metabolism of porphyrins pathway
Metabolism pathway
|
||||||||||||||
KEGG |
Porphyrin and chlorophyll metabolism pathway
|
||||||||||||||
INOH |
Porphyrin metabolism pathway
|
||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Mm.266888 Mm.391664 Mm.404005 Mm.478548 | ||||||||||||||
RefSeq | NM_008911 XM_006496707 XM_006496708 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS15487 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||