InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcd1

Summary

InnateDB Protein

IDBP-204351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcd1

Protein Name

phospholipase C, delta 1

Synonyms

AW212592; C79986;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010804

InnateDB Gene

IDBG-204349 (Plcd1)

Protein Structure

UniProt Annotation

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. {ECO:0000269PubMed:16314520}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, lung, epididymis and testis. Detected at lower levels in kidney and skeletal muscle. {ECO:0000269PubMed:10425196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0032794	GTPase activating protein binding
GO:0070300	phosphatidic acid binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97614

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM