InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plcd1

Summary

InnateDB Gene

IDBG-204349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcd1

Gene Name

phospholipase C, delta 1

Synonyms

AW212592; C79986

Species

Mus musculus

Ensembl Gene

ENSMUSG00000010660

Encoded Proteins

IDBP-204351

phospholipase C, delta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187091:
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:119071527-119093496

Strand

Reverse strand

Band

Transcripts

ENSMUST00000010804

ENSMUSP00000010804

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0032794	GTPase activating protein binding
GO:0070300	phosphatidic acid binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0060716	labyrinthine layer blood vessel development