InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrwd1

Summary

InnateDB Protein

IDBP-204389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrwd1

Protein Name

leucine-rich repeats and WD repeat domain containing 1

Synonyms

1200011O22Rik; AU042569; AW548074; Orca;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006301

InnateDB Gene

IDBG-204387 (Lrwd1)

Protein Structure

UniProt Annotation

Function

Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000250, ECO:0000269PubMed:22427655}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20180869}. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres (By similarity). Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:17074343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0035064	methylated histone binding

Biological Process

GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0016568	chromatin modification
GO:0071169	establishment of protein localization to chromatin

Cellular Component

GO:0005634	nucleus
GO:0005664	nuclear origin of replication recognition complex
GO:0005721	centromeric heterochromatin
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0031933	telomeric heterochromatin