InnateDB Protein
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IDBP-204419.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dedd
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Protein Name
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death effector domain-containing
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Synonyms
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CASP8IP1; Dedpro1; DEFT; FLDED1; KE05;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068419
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InnateDB Gene
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IDBG-204417 (Dedd)
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Protein Structure
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Function |
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro. {ECO:0000250, ECO:0000269PubMed:9774341}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95- mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:9774341}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0007283
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spermatogenesis
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GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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GO:0042177
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negative regulation of protein catabolic process
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GO:0042981
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regulation of apoptotic process
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GO:0046697
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decidualization
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GO:1901837
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negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
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Cellular Component |
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PDB ID |
MGI:1333874
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InterPro |
IPR001875
Death effector domain
IPR011029
Death-like domain
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PFAM |
PF01335
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PRINTS |
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PIRSF |
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SMART |
SM00031
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z1L3
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PhosphoSite |
PhosphoSite-Q9Z1L3
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TrEMBL |
Q3U001
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UniProt Splice Variant |
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Entrez Gene |
21945
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UniGene |
Mm.472271
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RefSeq |
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MGI ID |
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MGI Symbol |
Dedd
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OMIM |
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CCDS |
CCDS15490
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HPRD |
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IMGT |
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EMBL |
AC084821
AF100342
AJ011386
AK157342
BC023668
BC054445
CH466520
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GenPept |
AAD16415
AAH23668
AAH54445
BAE34055
CAA09604
EDL39096
EDL39097
EDL39098
EDL39099
EDL39100
EDL39101
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