InnateDB Protein
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IDBP-204427.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Accn1
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Protein Name
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amiloride-sensitive cation channel 1, neuronal (degenerin)
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Synonyms
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Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021045
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InnateDB Gene
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IDBG-204425 (Accn1)
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Protein Structure
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Function |
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. {ECO:0000269PubMed:14762118}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:15537887, ECO:0000269PubMed:15708491}; Multi-pass membrane protein {ECO:0000269PubMed:15537887, ECO:0000269PubMed:15708491}. Note=Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.
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Disease Associations |
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Tissue Specificity |
Expressed by sensory neurons. Expressed by nociceptive sensory neurons, spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. {ECO:0000269PubMed:14762118, ECO:0000269PubMed:15537887}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1100867
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InterPro |
IPR001873
Na+ channel, amiloride-sensitive
IPR004724
Epithelial sodium channel
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PFAM |
PF00858
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PRINTS |
PR01078
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q925H0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q78E63
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UniProt Splice Variant |
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Entrez Gene |
11418
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UniGene |
Mm.234998
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RefSeq |
NP_031410
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MGI ID |
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MGI Symbol |
Asic2
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OMIM |
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CCDS |
CCDS25137
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HPRD |
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IMGT |
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EMBL |
AF348465
AL626807
AL645626
AL645842
AL663025
BC138529
BC138530
CH466556
U57353
Y14634
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GenPept |
AAB49183
AAI38530
AAI38531
AAK40101
CAA74978
CAI24499
CAI24500
CAI25306
CAI25540
CAI25600
CAI25602
EDL15651
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