Version 5.4
Mus musculus Gene: Accn1
Summary
InnateDB Gene IDBG-204425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Accn1
Gene Name amiloride-sensitive cation channel 1, neuronal (degenerin)
Synonyms Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg
Species Mus musculus
Ensembl Gene ENSMUSG00000020704
Encoded Proteins
IDBP-204427
amiloride-sensitive cation channel 1, neuronal (degenerin)
IDBP-204429
amiloride-sensitive cation channel 1, neuronal (degenerin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108684:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:80880169-81968457
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000021045 ENSMUSP00000021045
ENSMUST00000066197 ENSMUSP00000067095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0022839 ion gated channel activity
Biological Process
GO:0001101 response to acid
GO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0007602 phototransduction
GO:0007605 sensory perception of sound
GO:0009612 response to mechanical stimulus
GO:0010447 response to acidity
GO:0010468 regulation of gene expression
GO:0019229 regulation of vasoconstriction
GO:0030193 regulation of blood coagulation
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035418 protein localization to synapse
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043066 negative regulation of apoptotic process
GO:0050915 sensory perception of sour taste
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051965 positive regulation of synapse assembly
GO:0071229 cellular response to acid
GO:0071468 cellular response to acidity
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108684
View Gene Order
ENSBTAG00000025200
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04742
Taste transduction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt Q925H0
TrEMBL B2RRQ1 Q78E63
UniProt Splice Variant
Entrez Gene 11418
UniGene Mm.234998
RefSeq NM_007384 NM_001034013
OMIM
CCDS CCDS25137 CCDS36243
HPRD
IMGT
MGI ID MGI:1100867
MGI Symbol Asic2
EMBL AF348465 AL626807 AL645626 AL645842 AL663025 BC138529 BC138530 CH466556 U57353 Y14634
GenPept AAB49183 AAI38530 AAI38531 AAK40101 CAA74978 CAI24499 CAI24500 CAI25306 CAI25540 CAI25600 CAI25602 EDL15651
RNA Seq Atlas 11418

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca