InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Accn1

Summary

InnateDB Protein

IDBP-204429.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Accn1

Protein Name

amiloride-sensitive cation channel 1, neuronal (degenerin)

Synonyms

Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067095

InnateDB Gene

IDBG-204425 (Accn1)

Protein Structure

UniProt Annotation

Function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. {ECO:0000269PubMed:14762118}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15537887, ECO:0000269PubMed:15708491}; Multi-pass membrane protein {ECO:0000269PubMed:15537887, ECO:0000269PubMed:15708491}. Note=Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons.

Disease Associations

Tissue Specificity

Expressed by sensory neurons. Expressed by nociceptive sensory neurons, spiral ganglion (SG) neurons and the retina (at protein level). Isoform 1 and isoform 2 are expressed in outer nuclear layer of retina (photoreceptors) and to a lower extent in distal and proximal inner nuclear layer. {ECO:0000269PubMed:14762118, ECO:0000269PubMed:15537887}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0022839	ion gated channel activity

Biological Process

GO:0001101	response to acid
GO:0003026	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0007602	phototransduction
GO:0007605	sensory perception of sound
GO:0009612	response to mechanical stimulus
GO:0010447	response to acidity
GO:0019229	regulation of vasoconstriction
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035418	protein localization to synapse
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043066	negative regulation of apoptotic process
GO:0050974	detection of mechanical stimulus involved in sensory perception
GO:0051965	positive regulation of synapse assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0045202	synapse