InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl11

Summary

InnateDB Protein

IDBP-204521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl11

Protein Name

chemokine (C-C motif) ligand 11

Synonyms

eotaxin; Scya11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000342

InnateDB Gene

IDBG-204519 (Ccl11)

Protein Structure

UniProt Annotation

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002544	chronic inflammatory response
GO:0002551	mast cell chemotaxis
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0008360	regulation of cell shape
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0048245	eosinophil chemotaxis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0070371	ERK1 and ERK2 cascade
GO:0070670	response to interleukin-4