InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Exosc10

Summary

InnateDB Protein

IDBP-204594.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Exosc10

Protein Name

exosome component 10

Synonyms

p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2; RRP6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095388

InnateDB Gene

IDBG-204588 (Exosc10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0008408	3'-5' exonuclease activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006396	RNA processing
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0044237	cellular metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0005622	intracellular
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1355322

InterPro

IPR002121 HRDC domain
IPR002562 3\'-5\' exonuclease domain
IPR010997 HRDC-like
IPR012337 Ribonuclease H-like domain
IPR012588 Exosome-associated factor Rrp6, N-terminal

PFAM

PF00570
PF01612
PF08066

PRINTS

PIRSF

SMART

SM00341
SM00474

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3TRD0

UniProt Splice Variant

Entrez Gene

50912

UniGene

Mm.468935

RefSeq

MGI ID

MGI Symbol

Exosc10

OMIM

CCDS

HPRD

IMGT

EMBL

AK162887 AL606969 AL713995

GenPept

BAE37100