InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Exosc10

Summary

InnateDB Gene

IDBG-204588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exosc10

Gene Name

exosome component 10

Synonyms

p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2; RRP6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017264

Encoded Proteins

IDBP-204590

exosome component 10

IDBP-204592

exosome component 10

IDBP-204594

exosome component 10

IDBP-628235

exosome component 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171824:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:148558429-148582401

Strand

Forward strand

Band

Transcripts

ENSMUST00000017408	ENSMUSP00000017408
ENSMUST00000076022	ENSMUSP00000075401
ENSMUST00000097781	ENSMUSP00000095388
ENSMUST00000150723	ENSMUSP00000133336
ENSMUST00000126897
ENSMUST00000173154
ENSMUST00000173767
ENSMUST00000173892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0004532	exoribonuclease activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000460	maturation of 5.8S rRNA
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006396	RNA processing
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0044237	cellular metabolic process
GO:0071028	nuclear mRNA surveillance
GO:0071034	CUT catabolic process
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
GO:0071044	histone mRNA catabolic process
GO:0071048	nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0035327	transcriptionally active chromatin

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171824

View Gene Order

ENSBTAG00000002590

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

50912

UniGene

Mm.266635 Mm.468935

RefSeq

NM_016699 XM_006535958 XM_006535959 XM_006539023

OMIM

CCDS

CCDS18939

HPRD

IMGT

MGI ID

MGI:1355322

MGI Symbol

Exosc10

EMBL

GenPept

RNA Seq Atlas

50912