InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F11r

Summary

InnateDB Protein

IDBP-204608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11r

Protein Name

F11 receptor

Synonyms

9130004G24; AA638916; ESTM33; JAM; JAM-1; JAM-A; Jcam; Jcam1; Ly106;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041907

InnateDB Gene

IDBG-204606 (F11r)

Protein Structure

UniProt Annotation

Function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:11036763}. Cell membrane {ECO:0000269PubMed:11036763}; Single-pass type I membrane protein {ECO:0000269PubMed:11036763}. Note=Localized at tight junctions of both epithelial and endothelial cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0009314	response to radiation
GO:0016032	viral process
GO:0030154	cell differentiation
GO:0030855	epithelial cell differentiation
GO:0045777	positive regulation of blood pressure

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle
GO:0036057	slit diaphragm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1321398

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88792