InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smpd1

Summary

InnateDB Protein

IDBP-204719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smpd1

Protein Name

sphingomyelin phosphodiesterase 1, acid lysosomal

Synonyms

A-SMase; ASM; aSMase; Zn-SMase;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042187

InnateDB Gene

IDBG-204717 (Smpd1)

Protein Structure

UniProt Annotation

Function

Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Biological Process

GO:0006685	sphingomyelin catabolic process
GO:0023021	termination of signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005764	lysosome
GO:0042599	lamellar body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98325

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PIRSF

PIRSF000948

SMART

SM00741

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt