InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smpd1

Summary

InnateDB Gene

IDBG-204717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smpd1

Gene Name

sphingomyelin phosphodiesterase 1, acid lysosomal

Synonyms

A-SMase; ASM; aSMase; Zn-SMase

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037049

Encoded Proteins

IDBP-204719

sphingomyelin phosphodiesterase 1, acid lysosomal

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166311:
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:105554360-105558388

Strand

Forward strand

Band

Transcripts

ENSMUST00000046983

ENSMUSP00000042187

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004767	sphingomyelin phosphodiesterase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds

Biological Process

GO:0006685	sphingomyelin catabolic process
GO:0023021	termination of signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0046513	ceramide biosynthetic process