InnateDB Protein
|
IDBP-204728.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Tmem127
|
Protein Name
|
transmembrane protein 127
|
Synonyms
|
2310003P10Rik; AI314202; AI317350;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000035434
|
InnateDB Gene
|
IDBG-204726 (Tmem127)
|
Protein Structure
|
|
Function |
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000250}.
|
Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0008285
|
negative regulation of cell proliferation
|
GO:0032007
|
negative regulation of TOR signaling
|
|
Cellular Component |
|
PDB ID |
MGI:1916720
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BGP5
|
PhosphoSite |
PhosphoSite-Q8BGP5
|
TrEMBL |
G3UZT7
|
UniProt Splice Variant |
|
Entrez Gene |
69470
|
UniGene |
Mm.474083
|
RefSeq |
NP_780354
|
MGI ID |
|
MGI Symbol |
Tmem127
|
OMIM |
|
CCDS |
CCDS16697
|
HPRD |
|
IMGT |
|
EMBL |
AK030324
AK050216
AK165880
AL845368
BC049832
|
GenPept |
AAH49832
BAC26902
BAC34129
BAE38434
CAM17442
|
|
|