InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tardbp

Summary

InnateDB Protein

IDBP-204743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tardbp

Protein Name

TAR DNA binding protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081142

InnateDB Gene

IDBG-204739 (Tardbp)

Protein Structure

UniProt Annotation

Function

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043922	negative regulation by host of viral transcription
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070935	3'-UTR-mediated mRNA stabilization