Version 5.4
Mus musculus Gene: Tardbp
Summary
InnateDB Gene IDBG-204739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tardbp
Gene Name TAR DNA binding protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041459
Encoded Proteins
IDBP-194722
TAR DNA binding protein
IDBP-204743
TAR DNA binding protein
IDBP-204745
TAR DNA binding protein
IDBP-270319
TAR DNA binding protein
IDBP-270323
TAR DNA binding protein
IDBP-270325
TAR DNA binding protein
IDBP-788385
TAR DNA binding protein
IDBP-718453
IDBP-628265
TAR DNA binding protein
IDBP-628266
TAR DNA binding protein
IDBP-788378
TAR DNA binding protein
IDBP-788382
TAR DNA binding protein
IDBP-788383
TAR DNA binding protein
IDBP-788386
TAR DNA binding protein
IDBP-788387
TAR DNA binding protein
IDBP-788389
TAR DNA binding protein
IDBP-788391
TAR DNA binding protein
IDBP-788394
TAR DNA binding protein
IDBP-788395
TAR DNA binding protein
IDBP-788396
TAR DNA binding protein
IDBP-788400
TAR DNA binding protein
IDBP-788404
TAR DNA binding protein
IDBP-788407
TAR DNA binding protein
IDBP-788409
TAR DNA binding protein
IDBP-788411
TAR DNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120948:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:148612382-148627019
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000095719 ENSMUSP00000093386
ENSMUST00000084125 ENSMUSP00000081142
ENSMUST00000045180 ENSMUSP00000038113
ENSMUST00000105702 ENSMUSP00000101327
ENSMUST00000105700 ENSMUSP00000101325
ENSMUST00000105699 ENSMUSP00000101324
ENSMUST00000147391 ENSMUSP00000140333
ENSMUST00000140897 ENSMUSP00000135135
ENSMUST00000172073 ENSMUSP00000130963
ENSMUST00000165113 ENSMUSP00000129342
ENSMUST00000188134 ENSMUSP00000139476
ENSMUST00000188380
ENSMUST00000188488 ENSMUSP00000140989
ENSMUST00000186729 ENSMUSP00000139547
ENSMUST00000189041
ENSMUST00000187937
ENSMUST00000186317
ENSMUST00000190552 ENSMUSP00000141052
ENSMUST00000191378 ENSMUSP00000140718
ENSMUST00000191450 ENSMUSP00000140832
ENSMUST00000190287 ENSMUSP00000140859
ENSMUST00000187939 ENSMUSP00000140928
ENSMUST00000186711 ENSMUSP00000140057
ENSMUST00000190630 ENSMUSP00000140385
ENSMUST00000189048 ENSMUSP00000140364
ENSMUST00000185824 ENSMUSP00000140110
ENSMUST00000190696 ENSMUSP00000139637
ENSMUST00000186947 ENSMUSP00000140529
ENSMUST00000185673 ENSMUSP00000141010
ENSMUST00000190478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043922 negative regulation by host of viral transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070935 3'-UTR-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120948
View Gene Order
ENSBTAG00000003697
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001003898 NM_001003899 NM_001008545 NM_001008546 NM_145556
OMIM
CCDS CCDS38967 CCDS38968 CCDS38969 CCDS38970 CCDS38971
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca