InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim3

Summary

InnateDB Protein

IDBP-204798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim3

Protein Name

tripartite motif-containing 3

Synonyms

BERP1; HAC1; Rnf22;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053384

InnateDB Gene

IDBG-204796 (Trim3)

Protein Structure

UniProt Annotation

Function

Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0015031	protein transport
GO:0016567	protein ubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome

Protein Structure and Domains

PDB ID

MGI:1860040

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR003649 B-box, C-terminal
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R1R2