InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim3

Summary

InnateDB Gene

IDBG-204796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim3

Gene Name

tripartite motif-containing 3

Synonyms

BERP1; HAC1; Rnf22

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036989

Encoded Proteins

IDBP-204798

tripartite motif-containing 3

IDBP-268038

tripartite motif-containing 3

IDBP-268040

tripartite motif-containing 3

IDBP-534582

tripartite motif-containing 3

IDBP-542381

tripartite motif-containing 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110171:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the \'RING-B-box-coiled-coil\' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:105604463-105633571

Strand

Reverse strand

Band

Transcripts

ENSMUST00000057525	ENSMUSP00000053384
ENSMUST00000106791	ENSMUSP00000102403
ENSMUST00000106789	ENSMUSP00000102401
ENSMUST00000156581
ENSMUST00000154218
ENSMUST00000150363
ENSMUST00000153371	ENSMUSP00000119910
ENSMUST00000140882
ENSMUST00000147044	ENSMUSP00000114822

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0015031	protein transport
GO:0016567	protein ubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005769	early endosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000110171

View Gene Order

ENSBTAG00000003565

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29290

RefSeq

NM_001285870 NM_001285873 NM_018880 XM_006508037 XM_006508038 XM_006508040

OMIM

CCDS

CCDS21655 CCDS72012

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas