InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ache

Summary

InnateDB Protein

IDBP-204840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ache

Protein Name

acetylcholinesterase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024099

InnateDB Gene

IDBG-204838 (Ache)

Protein Structure

UniProt Annotation

Function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

Subcellular Localization

Cell junction, synapse. Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side.

Disease Associations

Tissue Specificity

Predominates in most expressing tissues except erythrocytes where a glycophospholipid-attached form of ACHE predominates.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0016787	hydrolase activity
GO:0017171	serine hydrolase activity
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0043621	protein self-association
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0001919	regulation of receptor recycling
GO:0002076	osteoblast development
GO:0006581	acetylcholine catabolic process
GO:0007271	synaptic transmission, cholinergic
GO:0007416	synapse assembly
GO:0008152	metabolic process
GO:0019695	choline metabolic process
GO:0031623	receptor internalization
GO:0045212	neurotransmitter receptor biosynthetic process
GO:0048814	regulation of dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0051262	protein tetramerization
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031225	anchored component of membrane
GO:0031594	neuromuscular junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:87876

InterPro

IPR000997 Cholinesterase
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR014788 Acetylcholinesterase, tetramerisation domain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00135
PF07859
PF08674

PRINTS

PR00878

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21836