InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ache

Summary

InnateDB Gene

IDBG-204838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ache

Gene Name

acetylcholinesterase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023328

Encoded Proteins

IDBP-204840

acetylcholinesterase

IDBP-204842

acetylcholinesterase

IDBP-534147

acetylcholinesterase

IDBP-539087

acetylcholinesterase

IDBP-542676

acetylcholinesterase

IDBP-531686

acetylcholinesterase

IDBP-538958

acetylcholinesterase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18385943

[Homo sapiens] ACHE (acetylcholinesterase) expression is induced by hydrogen peroxide (H2O2) via the JNK/AP1/ ATF2 signalling pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087085:
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:137287519-137294466

Strand

Forward strand

Band

Transcripts

ENSMUST00000024099	ENSMUSP00000024099
ENSMUST00000085934	ENSMUSP00000083097
ENSMUST00000132191	ENSMUSP00000117452
ENSMUST00000138591	ENSMUSP00000121378
ENSMUST00000141123	ENSMUSP00000123295
ENSMUST00000150983
ENSMUST00000125195	ENSMUSP00000119813
ENSMUST00000137126	ENSMUSP00000123248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003990	acetylcholinesterase activity
GO:0004104	cholinesterase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0016787	hydrolase activity
GO:0017171	serine hydrolase activity
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0043621	protein self-association
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0001919	regulation of receptor recycling
GO:0002076	osteoblast development
GO:0006581	acetylcholine catabolic process
GO:0007271	synaptic transmission, cholinergic
GO:0007416	synapse assembly
GO:0008152	metabolic process
GO:0019695	choline metabolic process
GO:0031623	receptor internalization
GO:0045212	neurotransmitter receptor biosynthetic process
GO:0048814	regulation of dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0051262	protein tetramerization
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031225	anchored component of membrane
GO:0031594	neuromuscular junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm