InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad51l3

Summary

InnateDB Protein

IDBP-204855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad51l3

Protein Name

RAD51-like 3 (S. cerevisiae)

Synonyms

R51H3; Rad51l3; TRAD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018985

InnateDB Gene

IDBG-204851 (Rad51l3)

Protein Structure

UniProt Annotation

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single- stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single- stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000269PubMed:15109494}.

Disease Associations

Tissue Specificity

Highly expressed in brain followed by testis. Also expressed in heart, liver, kidney, spleen, lung and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0042148	strand invasion

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005657	replication fork
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Protein Structure and Domains

PDB ID

MGI:1261809

InterPro

IPR003593 AAA+ ATPase domain
IPR007694 DNA helicase, DnaB-like, C-terminal
IPR013632 DNA recombination and repair protein Rad51, C-terminal
IPR014774 Circadian clock protein KaiC/DNA repair protein RadA
IPR016467 DNA recombination and repair protein, RecA-like
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03796
PF08423
PF06745

PRINTS

PIRSF

PIRSF005856

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt