InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rad51l3

Summary

InnateDB Gene

IDBG-204851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad51l3

Gene Name

RAD51-like 3 (S. cerevisiae)

Synonyms

R51H3; Rad51l3; TRAD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018841

Encoded Proteins

IDBP-204855

RAD51-like 3 (S. cerevisiae)

IDBP-204857

RAD51-like 3 (S. cerevisiae)

IDBP-204859

RAD51-like 3 (S. cerevisiae)

IDBP-204861

RAD51-like 3 (S. cerevisiae)

IDBP-539118

RAD51-like 3 (S. cerevisiae)

IDBP-537838

RAD51-like 3 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:82876434-82890614

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018985	ENSMUSP00000018985
ENSMUST00000092844	ENSMUSP00000090520
ENSMUST00000021033	ENSMUSP00000021033
ENSMUST00000100718	ENSMUSP00000098284
ENSMUST00000146053	ENSMUSP00000117401
ENSMUST00000135963	ENSMUSP00000122477

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0042148	strand invasion

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005657	replication fork
GO:0005813	centrosome
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185379

View Gene Order

ENSBTAG00000019082

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03440

Homologous recombination pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03440

Homologous recombination pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q9EP65

UniProt Splice Variant

Entrez Gene

19364

UniGene

Mm.9286

RefSeq

NM_001277938 NM_001277941 NM_001277942 NM_011235 XM_006532587

OMIM

CCDS

CCDS36250 CCDS70267 CCDS70268

HPRD

IMGT

MGI ID

MGI:1261809

MGI Symbol

Rad51d

EMBL

AB052827 AB052831 AB052832 AL603745 AL646089

GenPept

BAB19976 BAB19977 BAB19981 BAB19982

RNA Seq Atlas

19364