InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trip6

Summary

InnateDB Protein

IDBP-204926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trip6

Protein Name

thyroid hormone receptor interactor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024119

InnateDB Gene

IDBG-204924 (Trip6)

Protein Structure

UniProt Annotation

Function

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019900	kinase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0030335	positive regulation of cell migration