InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rpsa

Summary

InnateDB Protein

IDBP-205055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rpsa

Protein Name

ribosomal protein SA

Synonyms

67kDa; 67lr; AL022858; Lamr; Lamr1; Lamrl1; MLR; P40; P40-3; P40-8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035105

InnateDB Gene

IDBG-205053 (Rpsa)

Protein Structure

UniProt Annotation

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). Enables malignant tumor cells to penetrate laminin tissue and vessel barriers. Activates precursor thymic anti- OFA/iLRP specific cytotoxic T-cell. May induce CD8 T-suppressor cells secreting IL-10. {ECO:0000255HAMAP-Rule:MF_03016, ECO:0000269PubMed:10697612, ECO:0000269PubMed:1374897, ECO:0000269PubMed:16453457, ECO:0000269PubMed:6301485, ECO:0000269PubMed:6302102}.

Subcellular Localization

Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C- terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). 37LRP shuttles to the nucleus upon midkine (MDK) binding. {ECO:0000255HAMAP-Rule:MF_03016}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005055	laminin receptor activity
GO:0043236	laminin binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006407	rRNA export from nucleus
GO:0006412	translation
GO:0007155	cell adhesion

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0005886	plasma membrane
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0030686	90S preribosome