Version 5.4
Mus musculus Protein: Tfr2
Summary
InnateDB Protein IDBP-205139.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfr2
Protein Name transferrin receptor 2
Synonyms Trfr2;
Species Mus musculus
Ensembl Protein ENSMUSP00000031729
InnateDB Gene IDBG-205137 (Tfr2)
Protein Structure
UniProt Annotation
Function Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Subcellular Localization Cell membrane; Single-pass type II membrane protein.Isoform 3: Cytoplasm.
Disease Associations
Tissue Specificity Predominantly expressed in liver. Also expressed in kidney, spleen, brain, lung, heart and muscle with very low expression in kidney, muscle and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004998 transferrin receptor activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006879 cellular iron ion homeostasis
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1354956
InterPro IPR003137 Protease-associated domain, PA
IPR007365 Transferrin receptor-like, dimerisation domain
IPR007484 Peptidase M28
PFAM PF02225
PF04253
PF04389
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKX3
PhosphoSite PhosphoSite-Q9JKX3
TrEMBL
UniProt Splice Variant
Entrez Gene 50765
UniGene Mm.21757
RefSeq NP_056614
MGI ID
MGI Symbol Tfr2
OMIM
CCDS CCDS39333
HPRD
IMGT
EMBL AF207741 AF207742 AF222895 AF312033 AK004848 AK004965 BC013654
GenPept AAF37272 AAH13654 AAK28830 AAL05976 AAL05977 BAB23614 BAB23705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca