Version 5.4
Mus musculus Gene: Tfr2
Summary
InnateDB Gene IDBG-205137.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfr2
Gene Name transferrin receptor 2
Synonyms Trfr2
Species Mus musculus
Ensembl Gene ENSMUSG00000029716
Encoded Proteins
IDBP-205139
transferrin receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106327:
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137569851-137587481
Strand Forward strand
Band G2
Transcripts
ENSMUST00000031729 ENSMUSP00000031729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004998 transferrin receptor activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006879 cellular iron ion homeostasis
GO:0006898 receptor-mediated endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106327
View Gene Order
ENSBTAG00000011738
Not yet available
Cross-References
SwissProt Q9JKX3
TrEMBL
UniProt Splice Variant
Entrez Gene 50765
UniGene Mm.21757
RefSeq NM_001289507 NM_001289509 NM_001289511 NM_015799 XM_006504591 XM_006504592 XM_006504593 XM_006504594 XM_006504595
OMIM
CCDS CCDS39333
HPRD
IMGT
MGI ID MGI:1354956
MGI Symbol Tfr2
EMBL AF207741 AF207742 AF222895 AF312033 AK004848 AK004965 BC013654
GenPept AAF37272 AAH13654 AAK28830 AAL05976 AAL05977 BAB23614 BAB23705
RNA Seq Atlas 50765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca