InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bub1

Summary

InnateDB Protein

IDBP-205156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bub1

Protein Name

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

Synonyms

AL022991; Bub1a; C80208; D2Xrf87;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028858

InnateDB Gene

IDBG-205152 (Bub1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007063	regulation of sister chromatid cohesion
GO:0008283	cell proliferation
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint
GO:0071174	mitotic spindle checkpoint
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1100510

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013212 Mad3/BUB1 homology region 1

PFAM

PF00069
PF07714
PF08311

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00777

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt