InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H6pd

Summary

InnateDB Protein

IDBP-205508.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H6pd

Protein Name

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Synonyms

AI785303; G6pd1; Gpd-1; Gpd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081134

InnateDB Gene

IDBG-205502 (H6pd)

Protein Structure

UniProt Annotation

Function

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}. Note=Microsomes, endoplasmic reticulum lumen. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004345	glucose-6-phosphate dehydrogenase activity
GO:0017057	6-phosphogluconolactonase activity
GO:0030246	carbohydrate binding
GO:0047936	glucose 1-dehydrogenase [NAD(P)] activity
GO:0050661	NADP binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006098	pentose-phosphate shunt
GO:0055114	oxidation-reduction process
GO:0097305	response to alcohol

Cellular Component

GO:0005739	mitochondrion
GO:0005788	endoplasmic reticulum lumen

Protein Structure and Domains

PDB ID

MGI:2140356

InterPro

IPR001282 Glucose-6-phosphate dehydrogenase
IPR005900 6-phosphogluconolactonase, DevB-type
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal

PFAM

PF00479
PF02781

PRINTS

PR00079

PIRSF

PIRSF000110

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt