InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl3

Summary

InnateDB Protein

IDBP-205584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl3

Protein Name

chemokine (C-C motif) ligand 3

Synonyms

AI323804; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001008

InnateDB Gene

IDBG-205582 (Ccl3)

Protein Structure

UniProt Annotation

Function

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in lung, spleen, and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004698	calcium-dependent protein kinase C activity
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0016004	phospholipase activator activity
GO:0016301	kinase activity
GO:0042056	chemoattractant activity

Biological Process

GO:0000165	MAPK cascade
GO:0001649	osteoblast differentiation
GO:0001775	cell activation
GO:0002548	monocyte chemotaxis
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006887	exocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007610	behavior
GO:0008360	regulation of cell shape
GO:0009636	response to toxic substance
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010818	T cell chemotaxis
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722	calcium-mediated signaling
GO:0023052	signaling
GO:0030335	positive regulation of cell migration
GO:0030593	neutrophil chemotaxis
GO:0030595	leukocyte chemotaxis
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042493	response to drug
GO:0043085	positive regulation of catalytic activity
GO:0043308	eosinophil degranulation
GO:0043491	protein kinase B signaling
GO:0043525	positive regulation of neuron apoptotic process
GO:0043615	astrocyte cell migration
GO:0043922	negative regulation by host of viral transcription
GO:0045671	negative regulation of osteoclast differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050729	positive regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050918	positive chemotaxis
GO:0051928	positive regulation of calcium ion transport
GO:0051930	regulation of sensory perception of pain
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070723	response to cholesterol
GO:0071407	cellular response to organic cyclic compound
GO:0071621	granulocyte chemotaxis
GO:2000503	positive regulation of natural killer cell chemotaxis