Version 5.4
Mus musculus Protein: Cyp8b1
Summary
InnateDB Protein IDBP-205769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp8b1
Protein Name cytochrome P450, family 8, subfamily b, polypeptide 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000052989
InnateDB Gene IDBG-205767 (Cyp8b1)
Protein Structure
UniProt Annotation
Function Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008397 sterol 12-alpha-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0033778 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1338044
InterPro IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88962
PhosphoSite PhosphoSite-O88962
TrEMBL
UniProt Splice Variant
Entrez Gene 13124
UniGene Mm.20889
RefSeq NP_034142
MGI ID
MGI Symbol Cyp8b1
OMIM
CCDS CCDS23641
HPRD
IMGT
EMBL AF090317 AF090319 BC010973 BC010974 BC049969
GenPept AAC63036 AAD19876 AAH10973 AAH10974 AAH49969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca