Version 5.4
| Mus musculus Gene: Cyp8b1 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-205767.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Cyp8b1 | ||||||||||||
| Gene Name | cytochrome P450, family 8, subfamily b, polypeptide 1 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000050445 | ||||||||||||
| Encoded Proteins |
cytochrome P450, family 8, subfamily b, polypeptide 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180432:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 9:121914356-121916305 | ||||||||||||
| Strand | Reverse strand | ||||||||||||
| Band | F4 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Cytochrome P450 - arranged by substrate type pathway
Phase 1 - Functionalization of compounds pathway
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Endogenous sterols pathway
Synthesis of bile acids and bile salts pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Biological oxidations pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Sterols are 12-hydroxylated by CYP8B1 pathway
Bile acid and bile salt metabolism pathway
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| KEGG |
Primary bile acid biosynthesis pathway
PPAR signaling pathway pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts pathway
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
Arachidonic acid metabolism pathway
Nicotinamide salvaging pathway
Nicotinate metabolism pathway
Sterols are 12-hydroxylated by CYP8B1 pathway
Endogenous sterols pathway
Eicosanoids pathway
Metabolism of lipids and lipoproteins pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Bile acid and bile salt metabolism pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Biological oxidations pathway
Disease pathway
Phase 1 - Functionalization of compounds pathway
Metabolism of vitamins and cofactors pathway
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| KEGG |
PPAR signaling pathway pathway
Primary bile acid biosynthesis pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | O88962 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 13124 | ||||||||||||
| UniGene | Mm.20889 | ||||||||||||
| RefSeq | NM_010012 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS23641 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:1338044 | ||||||||||||
| MGI Symbol | Cyp8b1 | ||||||||||||
| EMBL | AF090317 AF090319 BC010973 BC010974 BC049969 | ||||||||||||
| GenPept | AAC63036 AAD19876 AAH10973 AAH10974 AAH49969 | ||||||||||||
| RNA Seq Atlas | 13124 | ||||||||||||