InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirpa

Summary

InnateDB Protein

IDBP-206004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirpa

Protein Name

signal-regulatory protein alpha

Synonyms

AI835480; Bit; CD172a; P84; Ptpns1; SHP-1; SHPS-1; SIRP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099491

InnateDB Gene

IDBG-206000 (Sirpa)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006910	phagocytosis, recognition
GO:0006911	phagocytosis, engulfment
GO:0006928	cellular component movement
GO:0007010	cytoskeleton organization
GO:0007015	actin filament organization
GO:0007160	cell-matrix adhesion
GO:0016477	cell migration
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:108563

InterPro

IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite