Version 5.4
| Mus musculus Gene: Sirpa | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-206000.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Sirpa | ||||||||||||||||||||||
| Gene Name | signal-regulatory protein alpha | ||||||||||||||||||||||
| Synonyms | AI835480; Bit; CD172a; P84; Ptpns1; SHP-1; SHPS-1; SIRP | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000037902 | ||||||||||||||||||||||
| Encoded Proteins |
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
signal-regulatory protein alpha
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] SIRPA negatively regulates TLR4 or TLR3 dependent cytokine production through inhibition of NF-kappaB dependent signalling.
[Homo sapiens] SIRPA down-regulation is lipopolysaccharide (LPS) inducible and contributes to innate immune activation in macrophages.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198053:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 2:129592835-129632228 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | F1 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
DAP12 interactions pathway
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| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
IL1 pathway
IL6 pathway
Prolactin pathway
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| REACTOME |
Cell surface interactions at the vascular wall pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Hemostasis pathway
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| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.1682 | ||||||||||||||||||||||
| RefSeq | NM_001177646 NM_001177647 NM_001291019 NM_001291020 NM_001291021 NM_007547 XM_006498982 XM_006498983 XM_006498986 XM_006498987 XM_006498988 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS16729 CCDS50708 CCDS71142 CCDS71143 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||