InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acaca

Summary

InnateDB Protein

IDBP-206046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acaca

Protein Name

acetyl-Coenzyme A carboxylase alpha

Synonyms

A530025K05Rik; Acac; Acc1; Gm738;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099490

InnateDB Gene

IDBG-206042 (Acaca)

Protein Structure

UniProt Annotation

Function

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity). {ECO:0000250UniProtKB:P11497}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12360400, ECO:0000269PubMed:20952656}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003989	acetyl-CoA carboxylase activity
GO:0004075	biotin carboxylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001894	tissue homeostasis
GO:0006084	acetyl-CoA metabolic process
GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0008152	metabolic process
GO:0044268	multicellular organismal protein metabolic process
GO:0051289	protein homotetramerization
GO:0055088	lipid homeostasis
GO:2001295	malonyl-CoA biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:108451

InterPro

IPR000022 Carboxyl transferase
IPR000089 Biotin/lipoyl attachment
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011764 Biotin carboxylation domain
IPR013537 Acetyl-CoA carboxylase, central domain
IPR016185 Pre-ATP-grasp domain
IPR029045 ClpP/crotonase-like domain

PFAM