Version 5.4
| Mus musculus Protein: St5 | |||||||
|---|---|---|---|---|---|---|---|
| Summary | |||||||
| InnateDB Protein | IDBP-206181.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | St5 | ||||||
| Protein Name | suppression of tumorigenicity 5 | ||||||
| Synonyms | 2010004M01Rik; 2610305K15Rik; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000081789 | ||||||
| InnateDB Gene | IDBG-206177 (St5) | ||||||
| Protein Structure |
|
||||||
| UniProt Annotation | |||||||
| Function | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | |||||||
| Disease Associations | |||||||
| Tissue Specificity | |||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
|
||||||
| Gene Ontology | |||||||
Molecular Function |
|
||||||
| Biological Process |
|
||||||
| Cellular Component |
|
||||||
| Protein Structure and Domains | |||||||
| PDB ID | MGI:108517 | ||||||
| InterPro |
IPR001194
DENN domain IPR005112 dDENN domain IPR005113 uDENN domain |
||||||
| PFAM |
PF02141
PF03455 PF03456 |
||||||
| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00799
SM00801 SM00800 |
||||||
| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q924W7 | ||||||
| PhosphoSite | PhosphoSite-Q924W7 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 76954 | ||||||
| UniGene | Mm.407522 | ||||||
| RefSeq | |||||||
| MGI ID | |||||||
| MGI Symbol | St5 | ||||||
| OMIM | |||||||
| CCDS | CCDS21735 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AJ307670 BC030391 BC032266 BC051034 | ||||||
| GenPept | AAH30391 AAH32266 AAH51034 CAC38111 CAC38112 | ||||||