InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPN7

Summary

InnateDB Protein

IDBP-20626.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPN7

Protein Name

calpain 7

Synonyms

CALPAIN7; PALBH;

Species

Homo sapiens

Ensembl Protein

ENSP00000253693

InnateDB Gene

IDBG-20624 (CAPN7)

Protein Structure

UniProt Annotation

Function

Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0090541	MIT domain binding

Biological Process

GO:0006508	proteolysis
GO:0010634	positive regulation of epithelial cell migration
GO:0097264	self proteolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001300 Peptidase C2, calpain, catalytic domain
IPR007330 MIT
IPR022682 Peptidase C2, calpain, large subunit, domain III
IPR022683 Peptidase C2, calpain, domain III
IPR022684 Peptidase C2, calpain family

PFAM

PF00648
PF04212
PF01067

PRINTS

PR00704

PIRSF

SMART

SM00230
SM00745
SM00720

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt