InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lhx1

Summary

InnateDB Protein

IDBP-206275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lhx1

Protein Name

LIM homeobox protein 1

Synonyms

Lim1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018842

InnateDB Gene

IDBG-206273 (Lhx1)

Protein Structure

UniProt Annotation

Function

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. {ECO:0000269PubMed:7904966}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:8793615}.

Disease Associations

Tissue Specificity

In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptive lateral and intermediate mesoderm. Later, expression become progressively restricted to intermediate mesoderm, and the developing excretory system including the pronephric region, mesonephros, nephric duct and metanephros. In the metanephros, strongly expressed in renal vesicles and S-shaped and coma-shaped bodies, as well as in the ureteric bud and its derivatives. Also expressed in the dorsal root ganglia. By stage 10.5, also expressed in regions of the central nervous system in the telencephalon through to the spinal cord. In adults, expressed in the cerebellum/medulla and kidney, and at very low levels in the cerebrum. {ECO:0000269PubMed:7904966, ECO:0000269PubMed:7909459, ECO:0000269PubMed:8793615}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001655	urogenital system development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001702	gastrulation with mouth forming second
GO:0001705	ectoderm formation
GO:0001706	endoderm formation
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007389	pattern specification process
GO:0008045	motor neuron axon guidance
GO:0009653	anatomical structure morphogenesis
GO:0009791	post-embryonic development
GO:0009880	embryonic pattern specification
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0010842	retina layer formation
GO:0021510	spinal cord development
GO:0021517	ventral spinal cord development
GO:0021527	spinal cord association neuron differentiation
GO:0021537	telencephalon development
GO:0021549	cerebellum development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021871	forebrain regionalization
GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0032525	somite rostral/caudal axis specification
GO:0035502	metanephric part of ureteric bud development
GO:0035846	oviduct epithelium development
GO:0035847	uterine epithelium development
GO:0035849	nephric duct elongation
GO:0035852	horizontal cell localization
GO:0040019	positive regulation of embryonic development
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048793	pronephros development
GO:0060041	retina development in camera-type eye
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060065	uterus development
GO:0060066	oviduct development
GO:0060067	cervix development
GO:0060068	vagina development
GO:0060322	head development
GO:0060429	epithelium development
GO:0061205	paramesonephric duct development
GO:0072001	renal system development
GO:0072049	comma-shaped body morphogenesis
GO:0072050	S-shaped body morphogenesis
GO:0072077	renal vesicle morphogenesis
GO:0072164	mesonephric tubule development
GO:0072177	mesonephric duct development
GO:0072178	nephric duct morphogenesis
GO:0072224	metanephric glomerulus development
GO:0072278	metanephric comma-shaped body morphogenesis
GO:0072283	metanephric renal vesicle morphogenesis
GO:0072284	metanephric S-shaped body morphogenesis
GO:0090009	primitive streak formation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0097477	lateral motor column neuron migration
GO:2000543	positive regulation of gastrulation
GO:2000744	positive regulation of anterior head development
GO:2000768	positive regulation of nephron tubule epithelial cell differentiation