InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdgfa

Summary

InnateDB Protein

IDBP-206358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdgfa

Protein Name

platelet derived growth factor, alpha

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075463

InnateDB Gene

IDBG-206354 (Pdgfa)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0009887	organ morphogenesis
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
GO:0010544	negative regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910	regulation of smooth muscle cell migration
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043588	skin development
GO:0045740	positive regulation of DNA replication
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048839	inner ear development
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade