InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdgfa

Summary

InnateDB Gene

IDBG-206354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdgfa

Gene Name

platelet derived growth factor, alpha

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025856

Encoded Proteins

IDBP-206356

platelet derived growth factor, alpha

IDBP-206358

platelet derived growth factor, alpha

IDBP-259273

platelet derived growth factor, alpha

IDBP-259275

platelet derived growth factor, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197461:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:138976014-138997370

Strand

Reverse strand

Band

Transcripts

ENSMUST00000046901	ENSMUSP00000038870
ENSMUST00000076095	ENSMUSP00000075463
ENSMUST00000110897	ENSMUSP00000106522
ENSMUST00000110896	ENSMUSP00000106521
ENSMUST00000144934
ENSMUST00000124080
ENSMUST00000132051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001942	hair follicle development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009611	response to wounding
GO:0009887	organ morphogenesis
GO:0010033	response to organic substance
GO:0010035	response to inorganic substance
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
GO:0010544	negative regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910	regulation of smooth muscle cell migration
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0031954	positive regulation of protein autophosphorylation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0042060	wound healing
GO:0042493	response to drug
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043588	skin development
GO:0045740	positive regulation of DNA replication
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0048286	lung alveolus development
GO:0048839	inner ear development
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade