InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kmo

Summary

InnateDB Protein

IDBP-206448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kmo

Protein Name

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

Synonyms

AI046660;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095067

InnateDB Gene

IDBG-206446 (Kmo)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. {ECO:0000255HAMAP-Rule:MF_03018}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000255HAMAP-Rule:MF_03018}; Multi-pass membrane protein {ECO:0000255HAMAP-Rule:MF_03018}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004502	kynurenine 3-monooxygenase activity
GO:0016174	NAD(P)H oxidase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0009651	response to salt stress
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019674	NAD metabolic process
GO:0019805	quinolinate biosynthetic process
GO:0034354	'de novo' NAD biosynthetic process from tryptophan
GO:0043420	anthranilate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2138151

InterPro

IPR002938 Monooxygenase, FAD-binding
IPR003042 Aromatic-ring hydroxylase-like

PFAM

PF01494

PRINTS

PR00420

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91WN4

PhosphoSite

PhosphoSite-Q91WN4

TrEMBL

Q8CH15

UniProt Splice Variant

Entrez Gene

98256

UniGene

Mm.394680

RefSeq

MGI ID

MGI Symbol

Kmo

OMIM

CCDS

HPRD

IMGT

EMBL

AF482427 AK129011 BC014683

GenPept

AAH14683 AAO15720