Version 5.4
Mus musculus Gene: Kmo
Summary
InnateDB Gene IDBG-206446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kmo
Gene Name kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Synonyms AI046660
Species Mus musculus
Ensembl Gene ENSMUSG00000039783
Encoded Proteins
IDBP-206448
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
IDBP-206450
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
IDBP-542574
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117009:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:175620381-175662116
Strand Forward strand
Band H3
Transcripts
ENSMUST00000097458 ENSMUSP00000095067
ENSMUST00000040250 ENSMUSP00000038914
ENSMUST00000140474 ENSMUSP00000122943
ENSMUST00000142223
ENSMUST00000150646
ENSMUST00000137174
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004502 kynurenine 3-monooxygenase activity
GO:0016174 NAD(P)H oxidase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0009651 response to salt stress
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019674 NAD metabolic process
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0055114 oxidation-reduction process
GO:0070189 kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117009
View Gene Order
ENSBTAG00000014439
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_240936
Tryptophan catabolism pathway
KEGG
mmu00380
Tryptophan metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_916
Tryptophan catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt Q91WN4
TrEMBL Q8CH15
UniProt Splice Variant
Entrez Gene 98256
UniGene Mm.394680
RefSeq NM_133809
OMIM
CCDS CCDS15548
HPRD
IMGT
MGI ID MGI:2138151
MGI Symbol Kmo
EMBL AF482427 AK129011 BC014683
GenPept AAH14683 AAO15720
RNA Seq Atlas 98256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca