InnateDB Protein
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IDBP-206450.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kmo
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Protein Name
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kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
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Synonyms
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AI046660;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038914
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InnateDB Gene
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IDBG-206446 (Kmo)
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Protein Structure
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Function |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. {ECO:0000255HAMAP-Rule:MF_03018}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000255HAMAP-Rule:MF_03018}; Multi-pass membrane protein {ECO:0000255HAMAP-Rule:MF_03018}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2138151
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InterPro |
IPR002938
Monooxygenase, FAD-binding
IPR003042
Aromatic-ring hydroxylase-like
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PFAM |
PF01494
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PRINTS |
PR00420
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91WN4
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PhosphoSite |
PhosphoSite-Q91WN4
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TrEMBL |
Q8CH15
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UniProt Splice Variant |
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Entrez Gene |
98256
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UniGene |
Mm.394680
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RefSeq |
NP_598570
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MGI ID |
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MGI Symbol |
Kmo
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OMIM |
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CCDS |
CCDS15548
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HPRD |
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IMGT |
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EMBL |
AF482427
AK129011
BC014683
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GenPept |
AAH14683
AAO15720
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