Version 5.4
Mus musculus Protein: Lztfl1
Summary
InnateDB Protein IDBP-206456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lztfl1
Protein Name leucine zipper transcription factor-like 1
Synonyms 5530402H04Rik; 6130400H19Rik; AI414725; AW048545;
Species Mus musculus
Ensembl Protein ENSMUSP00000026274
InnateDB Gene IDBG-206454 (Lztfl1)
Protein Structure
UniProt Annotation
Function Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. {ECO:0000269PubMed:20233871, ECO:0000269PubMed:22093827}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:22072986, ECO:0000269PubMed:22093827}.
Disease Associations
Tissue Specificity Highly expressed in testis. Expressed in brain, cerebellum, eye, heart, kidney, liver, lung and trachea. In small intestine, graded expression along the crypt-villus axis with high levels in the villus apex and lower levels in the crypt stem cells (at protein level). Not expressed in skeletal muscle and white adipose tissue. {ECO:0000269PubMed:11352561, ECO:0000269PubMed:20233871, ECO:0000269PubMed:22072986, ECO:0000269PubMed:22093827}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034464 BBSome
Protein Structure and Domains
PDB ID MGI:1934860
InterPro IPR010989 t-SNARE
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHQ5
PhosphoSite PhosphoSite-Q9JHQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 93730
UniGene Mm.475504
RefSeq NP_201579
MGI ID
MGI Symbol Lztfl1
OMIM
CCDS CCDS40818
HPRD
IMGT
EMBL AJ297352 AK029671 AK041091 AK046515 AK054003 AK145263 AK157770 BC026840 BC098224
GenPept AAH26840 AAH98224 BAC26556 BAC30817 BAC32764 BAC35616 BAE26331 BAE34189 CAB95845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca