Version 5.4
Mus musculus Gene: Lztfl1
Summary
InnateDB Gene IDBG-206454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lztfl1
Gene Name leucine zipper transcription factor-like 1
Synonyms 5530402H04Rik; 6130400H19Rik; AI414725; AW048545
Species Mus musculus
Ensembl Gene ENSMUSG00000025245
Encoded Proteins
IDBP-206456
leucine zipper transcription factor-like 1
IDBP-206458
leucine zipper transcription factor-like 1
IDBP-622364
leucine zipper transcription factor-like 1
IDBP-622368
leucine zipper transcription factor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163818:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:123694416-123717625
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000026274 ENSMUSP00000026274
ENSMUST00000098258 ENSMUSP00000095858
ENSMUST00000165754
ENSMUST00000166097 ENSMUSP00000130872
ENSMUST00000168921 ENSMUSP00000132359
ENSMUST00000172067
ENSMUST00000163207
ENSMUST00000168923
ENSMUST00000166184
ENSMUST00000165799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0072594 establishment of protein localization to organelle
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034464 BBSome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163818
View Gene Order
ENSBTAG00000001484
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.378263 Mm.447499 Mm.475504
RefSeq NM_033322 XM_006512403
OMIM
CCDS CCDS40818
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca